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沈爱国，博士，中共党员，湖北潜江人，武汉纺织大学生物工程与健康学院教授，分析测试中心主任，博士生导师。中国物理学会光散射专业委员会副秘书长，湖北省化学化工学会谱学专业委员会秘书长。2006年7月毕业于武汉大学化学与分子科学学院分析化学专业，获博士学位（导师：胡继明教授）。毕业后留校任教并连续3年赴德国不来梅Jacobs大学和韩国全南国立大学开展国际合作研究。2008年12月晋升为副教授，2010年被遴选为博士生导师。2011年6月至2012年6月获德国DAAD-王宽诚博士后奖学金，在德国图宾根大学物理与理论化学所从事针尖增强拉曼光谱的合作研究（合作导师：Prof. Alfred J. Meixner）。2016年12月晋升为教授，2020年9月调入武汉大学印刷与包装系，2023年1月以学科带头人引进武汉纺织大学生物工程与健康学院工作，组建“分子指纹与生物医学实验室”。主要从事面向生命健康、环境和食品安全的生化传感、多光谱成像和仪器研制以及纺织品科技考古等领域的研究工作。先后主持1项国家重大科学仪器设备开发专项子项目，5项国家自然科学基金项目，1项中石油科技创新项目和2项国家重点实验室开放基金项目；参与1项国家自然科学基金仪器专项重点项目和1项国家重大研究计划培育项目。迄今已在Journalof the American Chemical Society, Angewandte Chemie International Edition, Advanced Functional Materials, Analytical Chemistry和ChemicalCommunications等杂志上发表SCI论文114篇，他引2900余次，H因子36。申请发明专利4项（其中3项已授权），参与编写“表面增强拉曼光谱原理及生物医学应用”相关的英文教材2部，受邀在国际和国内学术会议上作特邀报告20余次。
1. 主持人，国家自然科学基金面上项目，“新型有机半导体SERS基底的研制及其在高特异检测中的应用”，2025-2028，50万（直接经费），批准号：22474102。
2. 主持人，国家自然科学基金面上项目，“双重SERS指纹的液体活检新技术及其在消化道恶性肿瘤早期筛查中的应用”，2021-2024，63万（直接经费），批准号：22074109。
3. 主持人，企业横向项目，“变压器油中多种微量组分的SERS检测技术研究及便携式拉曼光谱系统、SERS芯片镀膜机样机研制”，2020-2022，258万。
4. 主持人，企业横向项目，“室内空气微生物快速检测关键技术及设备研发”，2020-2021，50万。
5. 主持人，海军工程大学协作开发项目，“表面增强拉曼光谱用于生活设施表面新冠病毒的快速识别研究”，2020-2021，20万。
1. WeiZhu, Er-Li Cai, Hao-Zheng Li, Ping Wang*, Ai-Guo Shen*,Juergen Popp*, Ji-Ming Hu*, Precise encoding of triple-bondRaman scattering of single polymer nanoparticles for multiplexed imaging application,Angewandte Chemie International Edition, 2021,60, 21846-21852.
2. YiZeng, Jia-Qiang Ren, Ai-Guo Shen*, Ji-Ming Hu,Splicing nanoparticles-based ‘Click’ SERS could aid multiplex liquid biopsy andaccurate cellular imaging, Journal of theAmerican Chemical Society, 2018, 140, 10649-10652.
3. Ai-Guo Shen,Li-Fang Chen, Wei Xie, Jun-Cheng Hu, Ao Zeng, Ryan M Richards, Ji-Ming Hu*,Triplex Au-Ag-C core-shell nanoparticles as a novel Raman label, Advanced Functional Materials, 2010,20, 969-975.
4. BiaoZhang, Jun Cao, Si-Jie Liao, Peng-Cheng Zhou, Yu-Ting Shen, Wei Yu, Wei Li, Ai-Guo Shen*,Simultaneous SERS sensing of cysteine and homocysteine in blood based on theCBT-Cys click reaction: Toward precisive diagnosis of schizophrenia, AnalyticalChemistry, 2024, 96,5331-5339.
5. Si-JieLiao, Jun Cao, Wei Zhu, Wei Li, Ji-Ming Hu, Ai-GuoShen*, Recent progress of responsiveRaman scattering probes for biosensing and bioimaging, TrAC-Trends inAnalytical Chemistry, 2024,169, 117357.
6. DongYu, Zong Liu, Chao-Kai Hu, Yao Shen, Zhi-Jiang Li*, Xin-Xin Zhang, Ai-Guo Shen*, Mass-producedmultiscale unclonable plasmonic security labels by a robotic wet-chemicalsystem, Chemical Engineering Journal, 2023,475, 146063.
7. Yao-YuPan, Bai-Chuan Zhao, Xin-Zhang, Wei Zhu, Ai-GuoShen*, "Dramatic growth" of microbialaerosols for visualization and accurate counting of bioaerosols, AnalyticalChemistry, 2023, 95,13537-13545.
8. DongYu, Yao Shen, Wei Zhu, Ji-Ming Hu, Ai-Guo Shen*,Raman inks based on triple-bond-containing polymeric nanoparticles for security,Nanoscale, 2022,14, 7864-7871.
9. JunCao, Tao Zhang, Wei Zhu, Hou-Bin Li, Ai-GuoShen*, A cooling-driven self-adaptiveand removable hydrogel coupled with combined chemo-photothermal sterilizationfor promoting infected wound healing, Nanoscale, 2023, 15, 11163-11178.
10. JunCao, Qing Sun, Ai-Guo Shen*,Bing Fan*, Ji-Ming Hu*, Nano Au@Cu2-xS withnear-infrared photothermal and peroxidase catalytic activities redefinesefficient antibiofilm-oriented root canal therapy, Chemical EngineeringJournal, 2021, 422,130090.
11. WeiZhu, Chun-Yang Wang, Ji-Ming Hu, Ai-Guo Shen*, Promoted"Click" SERS Detection for Precise Intracellular Imaging of Caspase-3,Analytical Chemistry, 2021,93, 4876-4883.
12. WeiFang, Biao Zhang, Fang-Yuan Han, Zhang-Na Qin, Yu-Qi Feng*, Ji-MingHu, and Ai-Guo Shen*,On-site and quantitative detection of trace methamphetamine in urine/serum sampleswith a surface-enhanced Raman scattering-active microcavity and rapid pretreatmentdevice, Analytical Chemistry, 2020,92, 13539-13549.
13. Meng-yueGao, Hao-Qing Jiang, Fang-Yuan Han, He-Xiang Deng*, Ji-Ming Hu,Ai-Guo Shen*, A laser metallurgy route for the batchpreparation of mm-scale 3D silver/graphite heteronanoclusters in air, Nanoscale,2020, 12,24054-24061.
14. WeiZhu, Meng-Yue Gao, Qing Zhu, Bin Chi, Ling-Wen Zeng, Ji-Ming Hu, Ai-GuoShen*, Monodispersed plasmonic prussian blue nanoparticlesfor zero-background SERS/MRI-guided phototherapy, Nanoscale, 2020, 12, 3292-3301.
15. YiZeng, Kevin M. Koo*, Ai-Guo Shen*, Ji-MingHu, Matt Trau*, Nucleic acid hybridization-based noise suppressionfor ultraselective multiplexed amplification of mutant variants, Small, 2021, 17, 2006370.
16. Meng-yueGao, Qiao Chen, Wei Li, Ai-Guo Shen*, Ji-Ming Hu, Combinedsurface-enhanced Raman scattering emissions for high-throughput optical labelson micrometer-scale objects, Analytical Chemistry, 2019, 91, 21, 13866-13873.
17.Wei Fang, Zi-He Cheng, Yin Yang, Ai-Guo Shen*, Ji-Ming Hu, Ultrafast andsurfactant-free synthesis of bimetallic alloy nanopeanuts:First-longitudinal-then-radial growth starting from slightly inert metal seeds,Applied Materials Today, 2019,15, 252-262.
18. YiZeng, Kevin M. Koo, Matt Trau*, Ai-GuoShen*, Ji-MingHu, Watching SERS glow for multiplex biomolecular analysis in the clinic: Areview, Applied Materials Today, 2019,15, 431-444.
19. Xiang-RuBai, Li-Hua Wang, Jia-Qiang Ren, Xiang-Wei Bai, Ling-Wen Zeng*, Ai-GuoShen*, Ji-Ming Hu, Accurate clinical diagnosis of livercancer based on simultaneous detection of ternary specific antigens by magneticinduced mixing surface-enhanced Raman scattering emissions, Analytical Chemistry, 2019, 91,2955-2963.
20. QianLv, Huan Min, Dong-Ban Duan, Wei Fang, Gui-Ming Pan, Ai-Guo Shen*,Qu-Quan Wang, Guang-Jun Nie*, Ji-Ming Hu, Total aqueous synthesis ofAu@Cu2-xS core-shell nanoparticles for in vitro and invivo SERS/PA imaging-guided photothermal cancer therapy, Advanced Healthcare Materials, 2019,8 (2), 1801257.
21. QianLv, Meng-Yue Gao, Zi-He Cheng, Qiao Chen, Ai-Guo Shen*,Ji-Ming Hu, Rational synthesis of hollow cubic CuS@Spiky Au core-shellnanoparticles for enhanced photothermal and SERS effects, Chemical Communications, 2018, 54, 13399-13402.
22. Jun-RongLi, Guan-Nan Zhang, Jing Wang, Ivan S. Maksymov, Andrew D. Greentree, Ji-Ming Hu,Ai-Guo Shen*, Yu-Ling Wang*, Matt Trau*,Facile one-pot synthesis of nanodot-decorated gold-silver alloy nanoboxes forsingle-particle surface-enhanced Raman scattering activity, ACS Applied Materials & Interfaces, 2018,10, 32526-32535.
23. Xiang-RuBai, Yi Zeng, Xiao-Dong Zhou, Xiao-Hua Wang, Ai-Guo Shen*,Ji-Ming Hu, Environmentally safe mercury (II) ions aided zero-background andultrasensitive SERS detection of dipicolinic acid, Analytical Chemistry, 2017, 89, 10335-10342.
24. YiZeng, Jia-Qiang Ren, Shao-Kai Wang, Jia-Ming Mai, Bing Qu, Yan Zhang, Ai-GuoShen*, Ji-Ming Hu, Rapid and reliable detection of alkalinephosphatase by a hot spots amplification strategy based on well-controlledassembly on single nanoparticle, ACSApplied Materials & Interfaces, 2017, 9, 29547-29553.
25.Yi Zeng, Jia-Qiang Ren, Ai-GuoShen*, Ji-Ming Hu*, Field and pretreatment-free detectionof heavy-metal ions in organic polluted water through an alkyne-coded SERS testkit, ACS Applied Materials &Interfaces, 2016, 8, 27772-27778.
26. YongChen, Jia-Qiang Ren, Xia-Guang Zhang, De-Yin Wu, Ai-Guo Shen*,Ji-Ming Hu*, Alkyne-modulated surface-enhanced Ramanscattering-palette for optical interference-free and multiplex cellularimaging, Analytical Chemistry, 2016,88, 6115-6119.
27.Wei Fang, Xin-Wei Zhang, Yong Chen,Liang Wan, Wei-Hua Huang, Ai-Guo Shen*, Ji-Ming Hu*,Portable SERS-enabled micropipettes for microarea sampling and reliablyquantitative detection of surface organic residues, Analytical Chemistry, 2015, 87, 9217-9224.
28. YiZeng, Jin-Ju Pei, Li-Hua Wang, Ai-Guo Shen*, Ji-MingHu, A sensitive sequential "on/off" SERS assay for heparin with widerdetection window and higher reliability based on the reversed surface chargechanges of functionalized Au@Ag nanoparticles, Biosensors and Bioelectronics, 2015, 66, 55-61.
29. Li-HuaWang, Yi Zeng, Ai-Guo Shen*, Xiao-Dong Zhou, Ji-MingHu*, Three-dimensional nano-assemblies of noble metalnanoparticle-infinite coordination polymers as specific oxidase mimetics fordegradation of methylene blue without adding any cosubstrate, Chemical Communications, 2015,51, 2052-2055.
30. GanQu, Guan-Nan Zhang, Zi-Tong Wu, Ai-Guo Shen*, Jian-BoWang, Ji-Ming Hu*, A "turn-off" SERS assay of heparin withhigh selectivity based on heparin-peptide complex and Raman labelled goldnanoparticles, Biosensors andBioelectronics, 2014, 60, 124-129.
31. Zi-TongWu, Yi-Zhen Liu, Xiao-Dong Zhou, Ai-Guo Shen*, Ji-MingHu*, A "turn-off" SERS-based detection platform forultra-sensitive detection of thrombin based on enzymatic assays, Biosensors and Bioelectronics, 2013,44, 10-15.
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