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主要从事微流控芯片的设计、加工及其用于生化检测,多功能纳米材料合成,纤维基检测试纸条开发以及便携化仪器搭建等方面的研究。先后主持或承担“国家重大科研仪器研制项目”课题,国家自然科学基金青年基金、湖北省自然科研基金、湖北省教育厅自然科学基金、教育部重点实验室开放课题、湖北省重点实验重点项目、武汉纺织大学国家级项目培育项目以及企业研发等多项项目。在Analytical Chemistry, Biosensors & Bioelectronics,Sensorsand Actuators B: Chemical, Analytica Chimica Acta,Microfluidicsand Nanofluidics, Analyst,Critical Reviews in Analytical Chemistry 等国际国内权威杂志上发表论文近40篇。申请和授权发明专利多项,多次在国际国内学术会议做报告及获奖,指导多名研究生获得国家奖学金及竞赛获奖。
1. 国家重大科研仪器研制项目,32527802,基于精细化分离的外泌体多组学联合检测分析系统,2025-01至2030-12,在研,主持子课题;
2.湖北省教育厅重点项目,分压式微流控芯片构建及其用于肿瘤微囊泡的诊断,在研,主持;
3. 国家自然科学基金,22204123,三维磁基微流检测平台的构建及其在多种呼吸道病毒即时检测中的应用,2023-01至 2025-12,结题,主持;
4. 湖北省自然科学基金,2022CFB1002,双信号多组分微流检测平台构建及其在流感病毒分型中的研究,2022-12至2024-12,结题,主持;
5. 湖北省教育厅,Q20211702,自动化编码芯片对多种冠状病毒的一步检测,2021-01至2022-12,结题,主持;
6. 武汉市应用基础前沿研究项目,2022013988065203,纤维基生物芯片开发及其用于多种呼吸道疾病的即时检测,结题,主持;
7. 教育部重点实验室开放课题,Fzxw2023015,纤维基微流体检测试纸条开发及其在呼吸道疾病即时检测中的应用,2023-01至2024-12,结题,主持;
8. 湖北省重点实验室重点项目,STRZ202205,纺织基微芯片开发及用于呼吸道疾病的即时检测,2022-12-08至2024-12,结题,主持;
9. 武汉纺织大学国家级培育项目,武纺大科[2019]5号,基于磁性和尺寸介导的微流控芯片同时检测多种流感病毒;2019-10至2021-12,结题,主持;
10.武汉纺织大学国家级培育项目,校2025247,基于微珠阵列芯片对微量龈沟液中多种牙周炎标志物进行同时检测的研究;2025-6至2025-12,结题,主持;
科研论文:
1. Ji, C.-X.; Li, W.-W.; Ding, J.-Y.; Xu, Y.; Xi, Y.-L.;Xu, J.-Y.; Lin, L.-P.; Li, W.; Yu, Z.-L.; Jia, J.*.; Hong, S.-L..*, AMicrochip-Based Gauge for Visual Prediction of Immunotherapy via DistanceReadout of Microvesicles. Anal. Chem. 2026.
2. Wang, X.; Ji, C.-X.; Liu, H.; Guan, H.-Y.; Wang, J.; Li, W*.;Zhu, Z.*; Hong, S.-L.*, A time-resolved luminescence assay using time-to-spaceconversion strategy for the sensitive detection of influenza virus on amicrofluidic chip. Biosens. Bioelectron. 2025, 287, 117679.
3. Ji, C.-X.; Zhang, M.-F.; Wang, X.; Liu, H.; Wu,M.-H.; Li, W.; Yu, Z.-L.; Hong,S.-L., Monolayer-Fluorescence Counting for UltrasensitiveDetection of Tumour Cell-Derived Extracellular Vesicles Using a Step-wedgeMicrofluidic Platform. Sens. Actuators B-Chem. 2024, 136786.
4. Yu, Z.-L.; Wu, Z.-Y.; Liu, X.-C.; Ji, C.-X.; Wang,X.; Fu, Q.-Y.; Chen, G.; Wu, M. *;Hong, S.-L*.; Jia, J. *, Predictive Analysis in Oral Cancer Immunotherapy: Profiling DualPD-L1-Positive Extracellular Vesicle Subtypes with Step-Wedge MicrofluidicChips. Anal. Chem. 2024.
5. Hong, S.-L.; Wang, X.; Bao, Z.-H.; Zhang, M.-F.; Tang, M.; Zhang, N.; Liu, H.; Zhu,Z.-Y.; Liu, K.; Chen, Z.-L.; Li, W., Simultaneous detection of multipleinfluenza virus subtypes based on microbead-encoded microfluidic chip. Anal.Chim. Acta 2023, 1279, 341773.
6. Hong,S. L.;Zhang, M. F.; Wang, X.; Liu, H. H.; Zhang, N. A.; Tang, M.; Li, W.,Magnetic-based Microfluidic Chip: A Powerful Tool for Pathogen Detection andAffinity Reagents Selection. Crit. Rev. Anal. Chem. 2023, 1-12.
7. Hong,S.-L.;Yu, Z.-L.; Bao, Z.-H.; Zhang, Q.-Y.; Zhang, N.; Tang, M.; Liu, S.-Q.; Jia, J.;Liu, K., One-step detection of oral ulcers and oral cancer derived exosomes onwedge-shaped and high magnetic field gradient mediated chip. Sens. Actuators B-Chem. 2022, 357, 131403.
8. Tang,M.; Chen, J.; Lei, J.; Ai, Z.; Liu, F.; Hong, S. L.*; Liu, K. *, Preciseand convenient size barcode on microfluidic chip for multiplex biomarkerdetection. Analyst 2021, 146 (19), 5892-5897.
9. Hong,S. L.;Zhang, N.; Qin, L.; Tang, M.; Ai, Z.; Chen, A.; Wang, S.; Liu, K., An automateddetection of influenza virus based on 3-D magnetophoretic separation andmagnetic label. Analyst 2021, 146 (3), 930-936.
10. Wang,S. #; Hong, S.#; Cai, S.; Lei, J.; Chen, J.;Zhang, N.; Ai, Z.; Liu, K.; Tang, M., Negative depletion mediated brightfieldcirculating tumour cell identification strategy on microparticle-basedmicrofluidic chip. Journal ofnanobiotechnology 2020, 18 (1), 70.(共一)
11. Wang,S.; Ai, Z.; Zhang, Z.; Tang, M.; Zhang, N.; Liu, F.; Han, G.; Hong, S. L.*;Liu, K.*, Simultaneous and automated detection of influenza A virushemagglutinin H7 and H9 based on magnetism and size mediated microfluidic chip.Sens. Actuators B-Chem. 2020, 308, 127675.
12. Hong,S. L.;Xiang, M. Q.; Tang, M.; Pang, D. W.; Zhang, Z. L., Ebola Virus Aptamers: FromHighly Efficient Selection to Application on Magnetism-Controlled Chips. Anal. Chem. 2019, 91 (5), 3367-3373. (X-MOL媒体报道)
13. Hong,S. L.;Wan, Y. T.; Tang, M.; Pang, D. W.; Zhang, Z. L., Multifunctional ScreeningPlatform for the Highly Efficient Discovery of Aptamers with High Affinity andSpecificity. Anal. Chem. 2017, 89 (12), 6535-6542. (X-MOL媒体报道)
14. Hong,S.-L.;Zhang, Y.-N.; Liu, Y.-H.; Tang, M.; Pang, D.-W.; Wong, G.; Chen, J.; Qiu, X.;Gao, G. F.; Liu, W.; Bi, Y.; Zhang, Z.-L., Cellular-Beacon-Mediated Countingfor the Ultrasensitive Detection of Ebola Virus on an Integrated MicromagneticPlatform. Anal. Chem. 2018, 90 (12), 7310-7317.
15. Zhang,R. Q.#; Hong, S. L.#; Wen, C. Y.; Pang, D. W.;Zhang, Z. L., Rapid detection and subtyping of multiple influenza viruses on amicrofluidic chip integrated with controllable micro-magnetic field. Biosens. Bioelectron. 2018, 100 (Supplement C), 348-354.
16. Hong,S.-L.;Tang, M.; Chen, Z.; Ai, Z.; Liu, F.; Wang, S.; Zhang, N.; Liu, K.,High-performance multiplex microvalves fabrication and using for tumor cellsstaining on a microfluidic chip. Biomed.Microdevices 2019, 21 (4), 87.
17. 洪少力; 庞代文; 张志凌, 磁控微流控芯片的研究现状及应用. 分析科学学报 2016, 32 (6), 877-884.
18. 唐蓉; 罗琪; 王烜; 李伟*; 洪少力*, 纺织基微流体的修饰与改性. 纺织工程学报 2023, 1 (05),50-56.
19. 黎雅琴; 胡玉江; 刘汉广; 高超; 熊金艳; 田迪; 洪少力*; 李伟*, 茜素在不同pH值的甲醇溶液中的存在形式(英文). 化学与生物工程 2023, 40 (09),27-34.
发明专利:
(1) 洪少力,秦莉,张泽芬,张琴韵,汤曼,张南刚,刘侃,一种病毒检测传感器、一种检测病毒浓度的装置和方法,CN110579603B
(2) 洪少力; 王烜; 张梦帆; 李伟 阶楔微流控芯片及制备方法和其结合单层荧光计数技术的生物应用. CN117380293A
(3) 洪少力; 汲长鑫; 王烜; 郑鹏; 李伟,分压微流控芯片、其制备方法和应用.CN118527188A

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